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Jay L Hess Selected Research

Proteins (Proteins, Gene)

12/2014The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.
10/2013Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion proteins.
9/2013MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction.
12/2012A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.
1/2012Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.
1/2011MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.
6/2010The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.
8/2009MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.
1/2009The role of menin in hematopoiesis.
3/2008HOX proteins and leukemia.
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Jay L Hess Research Topics

Disease

25Leukemia
04/2016 - 01/2004
8Neoplasms (Cancer)
10/2009 - 01/2004
3Congenital Preauricular Fistulae
09/2013 - 06/2010
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2017 - 01/2012
2Genetic Translocation (Chromosomal Translocation)
04/2015 - 01/2005
2Myeloid Leukemia (Leukemia, Myelocytic)
12/2007 - 01/2004
1Nonaka type Distal myopathy
12/2014
1Infections
12/2014
1Multiple Endocrine Neoplasia (Multiple Endocrine Adenomatosis)
01/2012
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2012
1Pancytopenia
05/2011
1Hematologic Diseases (Blood Diseases)
06/2009
1Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic)
01/2005
1Hyperplasia
01/2005
1Acute Myelomonocytic Leukemia
01/2005
1Myeloproliferative Disorders (Myeloproliferative Disorder)
01/2005
1T-Cell Leukemia (Leukemia, T Cell)
08/2004
1Multiple Endocrine Neoplasia Type 1
02/2004

Drug/Important Bio-Agent (IBA)

18Proteins (Proteins, Gene)FDA Link
12/2014 - 01/2004
7Histone MethyltransferasesIBA
04/2016 - 02/2004
5Transcription Factors (Transcription Factor)IBA
01/2016 - 01/2004
4MethyltransferasesIBA
01/2014 - 01/2004
4Histones (Histone)IBA
01/2006 - 01/2004
2ChromatinIBA
12/2014 - 08/2005
2Peptides (Polypeptides)IBA
12/2014 - 08/2004
2Oncogene Proteins (Oncogene Protein)IBA
10/2010 - 07/2006
2Lysine (L-Lysine)FDA Link
01/2006 - 02/2004
1lens epithelium-derived growth factorIBA
12/2014
1SolutionsIBA
12/2014
1IntegrasesIBA
12/2014
1HIV IntegraseIBA
12/2014
1MM-401IBA
01/2014
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
12/2012
1Myeloid-Lymphoid Leukemia ProteinIBA
12/2012
1Homeodomain Proteins (Proteins, Homeobox)IBA
01/2012
1RNA Polymerase II (RNA Polymerase B)IBA
06/2010
1OligonucleotidesIBA
08/2009
1DNA (Deoxyribonucleic Acid)IBA
08/2009
1CytokinesIBA
06/2008
1Amino AcidsFDA Link
03/2008
1RNA (Ribonucleic Acid)IBA
07/2006
1Small Interfering RNA (siRNA)IBA
07/2006
1Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA
01/2005
1Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2005
1Bortezomib (Velcade)FDA Link
08/2004
1Interleukin-6 (Interleukin 6)IBA
08/2004
1NF-kappa B (NF-kB)IBA
08/2004
1Interleukin-10 (Interleukin 10)IBA
08/2004
1Pharmaceutical PreparationsIBA
08/2004
1Proteasome InhibitorsIBA
08/2004
1Proteasome Endopeptidase Complex (Proteasome)IBA
08/2004
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
02/2004

Therapy/Procedure

6Therapeutics
01/2017 - 10/2004
2Drug Therapy (Chemotherapy)
10/2009 - 06/2009
1Hematopoietic Stem Cell Transplantation
01/2012
1Transplantation
05/2011